Poster or Presentation Title

Exposure to the SSRI Fluoxetine and its Effect on Learning and Memory in Adult Zebrafish

Access Type

Open Access

Presentation Type

Oral Presentation

Start Date

April 2017

End Date

April 2017

Department

Biomedical Science

Abstract

Since the beginnings of neurochemical research in the 1960s, the neurotransmitter serotonin has proved itself as an integral chemical in the maintenance of healthy brain chemistry. Serotonin’s activity has been linked to mood, sexual desire and function, appetite, sleep, memory and learning, temperature regulation, and some social behavior. That being said, imbalances in the chemical can lead to several mental health disorders, including depression and anxiety. These disorders are often treated with selective serotonin reuptake inhibitors (SSRIs), which block the reuptake of serotonin by the terminal buttons, allowing for the chemical to have a prolonged stay in the synapse. One of the most commonly prescribed SSRI medications for depression is fluoxetine, the generic prescription for Prozac. Effects on learning and memory are outside of fluoxetine’s known side effects, thus this study aimed to investigate the medicine’s impact on both learning and memory. Using adult Zebrafish exposed to varying levels (0μg/L, 50μg/L, 100μg/L, and 200μg/L) of waterborne fluoxetine, learning and memory was assessed with a T-maze procedure after one and then two weeks of exposure to the drug.

Faculty Mentor

Dr. Keith Corodimas

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Apr 5th, 1:15 PM Apr 5th, 1:30 PM

Exposure to the SSRI Fluoxetine and its Effect on Learning and Memory in Adult Zebrafish

Since the beginnings of neurochemical research in the 1960s, the neurotransmitter serotonin has proved itself as an integral chemical in the maintenance of healthy brain chemistry. Serotonin’s activity has been linked to mood, sexual desire and function, appetite, sleep, memory and learning, temperature regulation, and some social behavior. That being said, imbalances in the chemical can lead to several mental health disorders, including depression and anxiety. These disorders are often treated with selective serotonin reuptake inhibitors (SSRIs), which block the reuptake of serotonin by the terminal buttons, allowing for the chemical to have a prolonged stay in the synapse. One of the most commonly prescribed SSRI medications for depression is fluoxetine, the generic prescription for Prozac. Effects on learning and memory are outside of fluoxetine’s known side effects, thus this study aimed to investigate the medicine’s impact on both learning and memory. Using adult Zebrafish exposed to varying levels (0μg/L, 50μg/L, 100μg/L, and 200μg/L) of waterborne fluoxetine, learning and memory was assessed with a T-maze procedure after one and then two weeks of exposure to the drug.