Date Presented

Spring 4-1-2006

Document Type

Thesis

Degree Name

Bachelor of Science

Department

Biology

First Advisor

Anne Reeve

Second Advisor

Priscilla Gannicott

Third Advisor

Nancy Cowden

Abstract

Aspernigrin A is a compound correlated with inhibiting the growth of cancer cells in the colon. A five-step synthesis was designated for aspernigrin A, projected to yield four intermediates and the final product. The intermediates were analyzed by high field H-NMR and FT-IR spectroscopy before proceeding to the next step. A model pyridone ring system was successfully prepared from a commercially available pyrone precursor in two steps. These results provide a proof of concept that the synthetic scheme should successfully yield the natural product.

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