This clinical trial discusses the benefits of hCG therapy with concomitant use of aromatase inhibitors (AIs) in men on testosterone replacement therapy (TRT) to maintain fertility. Included in the discussion are studies and other trials outlining TRT. This study is targeted towards men on TRT and their female partners trying to achieve a pregnancy and focuses on the millions of American males suffering from decreased libido due to hypogonadism – a medical condition characterized by low testosterone levels. To increase testosterone levels, many males turn to TRT which may include weekly injections, topical ointments containing testosterone, or surgically implanted pellets releasing testosterone. A consequence of TRT is intra-testicular production of testosterone declines leading to infertility. Treatment with human chorionic gonadotropin (hCG) mimics the effects of luteinizing hormone (LH), a hormone that signals the testicles to produce testosterone. If males are able to remain on TRT to increase sexual libido while taking hCG to protect their endogenous testosterone, the goal is that fertility may be achieved. This study plans to use human subjects to analyze semen, intra-testicular testosterone and pregnancy outcomes in patients on TRT using hCG and AIs or selective estrogen receptor modulators (SERMs). The results support the theory that hCG can maintain fertility.
"The Use of hCG Therapy to Maintain Fertility in Men on TRT,"
Lynchburg Journal of Medical Science: Vol. 1
, Article 19.
Available at: https://digitalshowcase.lynchburg.edu/dmscjournal/vol1/iss2/19
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