Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Dr. Thomas Colletti, DHSc, PA-C


Sarcopenia is associated with increased mortality in patients with cirrhosis independent of Model for End Stage Liver Disease (MELD) score.There is evidence that reversal of muscle loss can improve survival. The best means by which to achieve reversal is still unknown. There is evidence supporting high protein diet, branched chain amino acids, testosterone therapy, and exercise among other modalities for the treatment of sarcopenia without clear cut guidelines.The hypothesis is that more than one modality will be needed to reverse muscle loss. Identifying treatment options will enable clinicians to provide adequate evidence to patients allowing them to participate in formulating an individualized plan for therapy.


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