Recent research advances have furthered the understanding of Alzheimer's Disease (AD). It is now understood that the pathophysiological changes begin years before the disease manifests clinically and that the AD spectrum spans from clinically asymptomatic to severely impaired. In addition, there is a transition underway to identify the disease progression based on both clinical and biomarker indicators, instead of diagnosis based solely on its clinical presentation as has been done historically. Advances in biomarker technology have helped facilitate this shift, with an increased recognition that AD should not be viewed simply as well-defined clinical stages, but as a complex progression along a continuum. While the exact pathophysiology is still yet unclear, the evidence supports researchers and clinicians adopting this disease continuum concept in the evaluation, diagnosis, and management of AD.
Haney, Amy A.
"Update on Alzheimer's Dementia: Pathophysiology, Disease Continuum, and Emerging Therapies,"
Lynchburg Journal of Medical Science: Vol. 1
, Article 31.
Available at: https://digitalshowcase.lynchburg.edu/dmscjournal/vol1/iss3/31
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