University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Orthopedic Surgery


Dr. Elyse Watkins


  • Orthopedic procedures involving metallic implants are increasingly common with projection in future growth.
  • There remains some debate regarding the local and systemic impact of metal induced allergic reactions following implantation of orthopedic instrumentation.
  • To date, there is no accepted universal standard for a valid, cost-effective diagnostic approach to detect metal hypersensitivity in patients scheduled to undergo implantation of a prosthetic device orwho have already undergone such a procedure.
  • Inpatients who are scheduled for a surgery involving a metallic implant who are known to have allergic reactions to worn or implanted metal, research supports a role for skin patch testing with possible follow up lymphocyte transformation testing as a safe and cost-effective way to improve patient outcomes and possibly reduce the need for future revision surgery.
  • A review of the literature regarding the incidence and clinical significance of metal hypersensitivity and to help understand the role for testing in the prevention of allergic reactions to orthopedic implants.


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