In patients with Pulmonary Tuberculosis will higher doses of Rifampicin/Rifampin coupled with a shorter treatment regimen as oppose to standard dosing and therapy result in better treatment response?

Authors

Giuseppe A. Screnci, University of LynchburgFollow

Specialty

Infectious DIsease

Advisor

Dr. Elyse Watkins

Abstract

Currently,the prescribed recommended dose of rifampicin is 10mg/kg or a 600mg daily. This dose was developed as the minimum effective dose over 50 years ago. The obstacle to effective clinical control in outpatient tuberculosis (TB) therapy is compliance due to a lengthy one year of therapy combined withrifampicin at 600mg daily dosing.It is known that treatment completion remains a significant challenge in the United States (US) with only 30% to 64% of patients completing treatment causing more resistance and more transmission of the disease to a vulnerable unknowing population. Eradication of TB weighs heavily on upgrading of the medication dosing regimens thus providing a quicker sputum culture conversion, resulting in a decrease transmission of the disease.Shortening TB treatment to six months and correspondingly increasing the dose of rifampicin to 1200mg daily dosing was associated with better results at achieving a quicker sputum culture conversion.

Recommended Citation

Screnci GA. In patients with Pulmonary Tuberculosis will higher doses of Rifampicin/Rifampin coupled with a shorter treatment regimen as oppose to standard dosing and therapy result in better treatment response?. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2019; 1(3).