University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Infectious DIsease


Dr. Elyse Watkins


Currently,the prescribed recommended dose of rifampicin is 10mg/kg or a 600mg daily. This dose was developed as the minimum effective dose over 50 years ago. The obstacle to effective clinical control in outpatient tuberculosis (TB) therapy is compliance due to a lengthy one year of therapy combined withrifampicin at 600mg daily dosing.It is known that treatment completion remains a significant challenge in the United States (US) with only 30% to 64% of patients completing treatment causing more resistance and more transmission of the disease to a vulnerable unknowing population. Eradication of TB weighs heavily on upgrading of the medication dosing regimens thus providing a quicker sputum culture conversion, resulting in a decrease transmission of the disease.Shortening TB treatment to six months and correspondingly increasing the dose of rifampicin to 1200mg daily dosing was associated with better results at achieving a quicker sputum culture conversion.


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