University of Lynchburg DMSc Doctoral Project Assignment Repository
Specialty
Pediatrics
Advisor
Dr. Thomas Colletti
Abstract
Cystic Fibrosis-related Liver Disease (CFLD) is highly prevalent in the first decade of life. Nearly 10% of children with Cystic Fibrosis will develop cirrhosis and 1-3% of those with cirrhosis will require liver transplant. The purpose of this review article is to examine the current diagnostic criteria and propose options for new diagnostic criteria based on recent studies. Current diagnostic criteria are based on data from 1999 and does not discuss recommendations for imaging studies for CFLD screening. Imaging can help provide early detection of CFLD when ordered promptly and not delayed by waiting for abnormal physical exam findings or extremely high liver function tests. This article will also discuss current management and complications of CFLD. This author suggests utilizing ultrasound and/or fibroscan as a screening tool along with physical exam and laboratory testing for CFLD for all Cystic Fibrosis patients ages 5-15 on an annual to biannual basis, dependent upon findings.
Recommended Citation
Toner RE. Liver Disease in Children with Cystic Fibrosis. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2019; 1(3).
Restricted
Available when accessing via a campus IP address or logged in with a University of Lynchburg email address.
Off-campus users can also use 'Off-campus Download' button above for access.