Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Pediatric Bone Marrow Transplant


Dr. Nancy Reid



Purpose: The purpose of this article is to provide physician assistants with a review of the signs, symptoms, diagnosis, management, and preventative measures for mucositis in the pediatric bone marrow transplant population.

Method: A PubMed literature search was conducted with search terms Palifermin, pediatric mucositis, oral mucositis, mucositis management, Palifermin use in pediatrics.Thirty-three articles were retrieved and will serve as the basis for this clinical review.

Results:Oral mucositis increases morbidity and mortality in the pediatric bone marrow transplant population. There is a lack of evidence-based research to demonstrate the utility of methods to prevent mucositis in the pediatric population.

Conclusion: More prospective and retrospective information is needed to determine the most effective ways to prevent and manage mucositis.

Keywords: pediatrics, mucositis, Palifermin, hematopoietic cell transplant, leukemia, total body irradiation, Palifermin.


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