University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Elyse Watkins, PhD, PA-C



Purpose: The purpose of this article is to review the available data on risk of HCC in NAFLD and NASH.

Method: A PubMed literature search was conducted with search terms HCC, NASH, NAFLD. and fatty liver. Eight articles were examined as the basis for the review article.

Results: While there are not current guidelines for screening for HCC in the non-cirrhotic NAFLD/NASH population, the data reviewed clearly shows a risk of HCC in this population.

Conclusion: NASH and NAFLD, regardless of the degree of liver fibrosis, present a risk for development of HCC. While current recommendations exist for screening cirrhotic patients for HCC, no guidance exists for screening in the non-cirrhotic population. Further data on the long term outcomes of screening in non-cirrhotic patients, as well as cost analysis of screening, is warranted in order to better inform future guidance committees.

Keywords: NASH, NAFLD, fatty liver, non-cirrhotic, HCC, hepatocellular carcinoma


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