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Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science

Specialty

Family Medicine

Advisor

Dr. Nancy Reid, MHA, DHSc, PA-C

Abstract

An increase in the incidence of type 2 diabetes mellitus (T2DM) worldwide finds us amid a global diabetes epidemic. Epidemiologic data suggest a link between hyperglycemia and increased cardiovascular risk, with the presence of diabetes increasing one's risk for developing cardiovascular disease (CVD) by two-to-fourfold. Consequently, almost all patients with T2DM are placed prophylactically on statin-therapy to decrease adverse CVD outcomes. A surplus of evidence-based research has shown an association between the use of statin therapy and the overall risk of developing diabetes mellitus. In addition, statin therapy has been shown to further increase hyperglycemia in patients who were already diagnosed with T2DM. This study reviews the current literature to address whether the risk of statin-induced insulin resistance in patients with T2DM outweigh its cardiovascular benefits.

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