Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Primary care


Dr. Elyse Watkins


The purpose of this article is to review the use of sub-anesthetic dosing of ketamine for resolution of suicidal ideation (SI) in emergency departments (ED). Based on properties of esketamine being a rapid-acting antidepressant for patients with treatment-resistant depression (TRD), one can extrapolate that improving TRD will have a direct correlation on the decrease of SI.1 In patients with TRD and SI, the use of sub-anesthetic intravenous use of ketamine has shown to improve both. Since Esketamine approval for TRD, there is promise that similar results could be achieved with subanesthetic doses of ketamine for acute SI.


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