Elyse Watkins DHSc, PA-C, AFAAPA
Hemorrhagic shock and death from exsanguination remain common following traumatic injury. Attaining rapid hemostasis through control of bleeding, correction of acidosis, prevention of hypothermia, and maximization of coagulation can decrease mortality. Hemostasis remains challenging secondary to coagulopathy from dysfunctional hyperfibrinolysis, which is observed following major trauma and physiologic stress. Hyperfibrinolysis leads to clot degradation and ongoing blood loss. Early administration of Antifibrinolytic agents such as Tranexamic Acid (TXA) can reduce mortality in patients with traumatic hemorrhage.
Cossey, Jason L.
"The Role of Antifibrinolytics in The Management of Traumatic Hemorrhage,"
Lynchburg Journal of Medical Science: Vol. 2
, Article 10.
Available at: https://digitalshowcase.lynchburg.edu/dmscjournal/vol2/iss1/10
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