University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Primary Care


Dr. Nancy Reid, MHA, DHSc, PA-C, DFAAPA



Purpose: The purpose of this article is to review the efficacy of treating Attention Deficit Hyperactivity Disorder (ADHD) in the outpatient setting with bupropion.

Method: A review of medical literature was performed to obtain superior study results regarding the usage of bupropion for the treatment of ADHD. Efforts were made to only include studies with level 2 evidence or higher. Searches were performed using PubMed, The Cochrane Library, and Medline. The search terms included ADHD, bupropion and ADHD, Wellbutrin® and ADHD, as well as bupropion and clinical trial and ADHD. These articles were utilized as the basis for this clinical review.

Results: There is sufficient evidence to postulate that bupropion is an effective treatment option for ADHD within the outpatient setting.

Conclusion: Bupropion is an anti-depressant medication that has been traditionally utilized for depression, anxiety, smoking cessation, and weight loss. Several studies have demonstrated that bupropion is superior to placebo in the treatment of ADHD. Further research will need to be performed to evaluate the efficacy of bupropion versus traditional ADHD treatments as well as a head to head comparison of side effect profiles.

Key Words: Attention Deficit Hyperactivity Disorder, Bupropion, Wellbutrin®


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