University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Occupational Medicine


Kathleen Gray, Matthew Probst, Danny Rumley



Purpose: The purpose of this article is to review the treatment of obesity and the effectiveness of lifestyle modification with the use of a pharmacologic treatment.

Method: A PubMed literature search was conducted with search terms obesity, lifestyle modification, and pharmacologic treatment. Nineteen pertinent articles were retrieved and serve as the basis for this clinical review.

Results: Medications and lifestyle modifications produce additional weight loss relative lifestyle modification alone.

Conclusion: Patients who are treated with medications approved for obesity and lifestyle modifications have a greater mean weight loss and is likely to achieve a greater amount of weight loss than lifestyle modification alone. There are a variety of over-the-counter and prescription weight loss drugs available. Weight loss medication approved by the U.S. Food and Drug Administration (FDA) for treating obesity include orlistat and lorcaserin, phentermine plus topiramate, Liraglutide, and Naltrexone/Bupropion. Further research must be done to further determine the long-term benefits and effects of these medications.


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