University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Medical Oncology


Dr. Reid, Nancy


Localized prostate cancer is defined by the American Joint Committee on Cancer (AJCC) as no evidence that the cancer has spread outside the prostate gland, this includes stage I, II, and some stage III prostate cancers.1,2 This article will explore different management modalities for early stage or localized prostate cancer, factors that might impact choice of treatment, patient outcome and overall survival based on selected treatment. Although there are many treatment modalities for localized prostate cancer, there is not a consensus among researchers of which treatment is superior over the others. Factors that affect the treatment choices are patient age, extent of tumor, histologic grade, Gleason score (GS), Prostate Specific Antigen (PSA) level, patient and physician state of residence, and physician specialty (urology, radiation/medical oncology). Among all factors, patient age seems to be the key prognostic factor for initial treatment decision and overall survival.3,4


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