Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Dr. Thomas Colletti



Purpose:The purpose of this article is to compare and analyze acetylcholinesterase inhibitor (AChEI) as an oral medication versus Cognitive Stimulation Therapy (CST) in the treatment of mild to moderate dementia.

Method:A literature search was conducted via PubMed utilizing search terms: behavioral psychiatric symptoms of dementia, dementia (BPSD), Alzheimer’s, disease, cognitive, stimulation, therapies, and acetylcholinesterase inhibitor. The search yielded twenty-one applicable articles to be used as the root for the clinical review. The group was re-evaluated to scrutinize both AChEI’s and CST in slowing the effects of dementia.

Results: The evidence-based research for CST versus the use of AChEI’s was inconclusive in defining a single gold standard for the treatment of dementia for the purpose of slowing the process of the disease.

Conclusion:Both CST and AChEI may be keys to slowing the process of this non-curable disease and improve theQuality of Life (QOL) for both the patient affected with the disease and their caregivers. Combination therapy of CST and AChEI’s appear to have a synergistic effect on improving the overall QOL. Further research is required in order to establish a gold standard in the treatment fordementia.

Keywords: Alzheimer’s disease, Acetylcholinesterase inhibitors, cognitive stimulation, elderly, physical exercise.

Appendix 1 Figure 1.docx (80 kB)
Figure 1

Appendix 1 Table 1.docx (138 kB)
Table 1


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