Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Occupational Health/Urgent Care/Toxicology


Dr Colletti



Purpose: The purpose of this article is to review the variety of methods used for PRP therapy. In the process, a focus will be placed on identifying factors that may provide for the best practices of obtaining donor platelets for PRP and exploring the literature for conditions that could enhance or limit the effects of PRP.

Method: A Pub Med literature search was conducted with search terms PRP, platelet rich plasma, orthobiologics, musculoskeletal, nanoparticles, antibodies, mathematical. Twelve pertinent articles were retrieved and served as the basis for this clinical review.

Results: A collection of data leading to useful recommendations for the ideal formulation parameters for various PRP preparations steps.

Conclusion: PRP is an injectable, biologic therapy that utilizes autologous platelet preparations to stimulate the healing of damaged soft tissues. Many studies have been performed to compare PRP with similar treatment modalities. A significant number of research studies present a mixed review of the efficacy for PRP versus other treatment therapies. It is possible that measurable differences in platelet preparations, patient medical conditions and medications may have obscured the results of previous studies. More research is needed to formulate a universal protocol for PRP in select body regions. This protocol must provide protocol modifications for patient specific PRP profiles. This approach should include tailored collection factors that will provide a more effective and uniform protocol for the accurate record of PRP efficacy.


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