University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Internal Medicine


Dr. Nancy Reid



Purpose: The purpose of this article is to review the factors that affect the flare-up of gout in the

adult population.

Method: The following sites were used to conduct research: PubMed, Journal of Medicine,

Elsevier Science Direct, American College of Rheumatology, CrossMark, BMJ, Arthritis

Research Therapy. Sixteen pertinent articles were retrieved, and they served as the basis for

this clinical review.

Results: Patient education and counseling adjunct with therapy are under investigation to

improve gout treatment often showing encouraging results.¹

Conclusion: A large proportion of patients with gout also have comorbid diseases. Obesity and

hypertension were common comorbidities among patients who developed flares. Additionally,

several lifestyle factors such as obesity and high alcohol intake were related to the risk of gout

flares. Moreover, some of these underlying conditions that could also impact treatment which

also makes them modifiable risk factors for flares. Further lifestyle changes can prevent the

flare-up and worsen of gout conditions.¹

Keywords: gout, hyperuricemia, flares, lifestyle modification, alcohol, high fructose-sweetened drinks.


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