University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Dr. Elyse Watkins



Orofacial Granulomatosis (OFG) is also known by synonyms such as cheilitis, or Melkersson-Rosenthal syndrome. Orofacial granulomatosis, describes several conditions in which granulomatous inflammation of soft tissues in the oral and maxillofacial region occur. Such conditions present with enlargement of the lips, and very often the surrounding oral tissue. The patient may also experience ulcers of the oral cavity, swelling, and inflammation of the gingiva. These signs may be variable, and it is the varied presentation that can make this disease entity hard to diagnose. OFG may present as a “stand alone” condition; or may occur as part of systemic conditions such as Crohn’s disease (CD), sarcoidosis, Melkersson-Rosenthal syndrome (generally with a fissured tongue as well), or granulomatosis with polyangiitis.1 Keywords: cheilitis, non-caseating granuloma, orofacial granulomatosis, and Melkersson-Rosenthal syndrome.


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