Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Emergency Medicine


Nancy Reid


Diabetic ketoacidosis is a common metabolic derangement due to a triad of hyperglycemia, anion gap metabolic acidosis, and ketonemia. The relatively recent introduction of sodium-glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus has led to increasing reports of euglycemic diabetic ketoacidosis. The mild elevation to near-normal levels of blood glucose can cause misdiagnosis or delay in initiating appropriate medical therapy, potentially resulting in adverse metabolic consequences. Clinicians should include in the differential diagnosis euglycemic diabetic ketoacidosis when patients present with metabolic acidosis or ketosis while prescribed sodium-glucose cotransporter-2 inhibitors.


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