Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Nancy Reid, MHA, DHSc, PA-C



Purpose: The purpose of this article is to review literature to assess if intra-articular knee injections of dHACM could be effective in treating mild to moderate knee osteoarthritis.

Method: A PubMed, AAOS, NEJM, EBSCO and Ovid, literature search was conducted with search terms knee osteoarthritis, biologic injection, stem cell, cell therapy, amnion and chorion. Numerous pertinent articles regarding knee osteoarthritis were retrieved along with thirteen articles more specific to the use of dHACM. These articles serve as the basis for this clinical review.

Results: Evidence-based literature regarding the application of dHACM in treating human osteoarthritis is lacking, however studies indicate a positive response that may be effective in treating mild to moderate symptomatic OA of the knee.

Conclusion: dHCM has shown to stimulate a healing response with migration of progenitor cells that can repair soft tissue damage. This migration has shown to be effective in healing diabetic foot ulcers, burn wounds and venous ulcers that have been historically difficult to treat. Using the concepts learned from the utilization of dHACM in these settings, the application of dHACM in treating cartilaginous degeneration of knee osteoarthritis shows potential through in-vivo and in-vitro studies in lab animals. Further research is needed to establish an indication for the use of dHACM in treating human osteoarthritis.


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