Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Dr. Nancy Reid


Purpose: The purpose of this article is to review the efficacy of immunotherapy in estrogen positive metastatic breast cancer.

Method: A PubMed literature search was conducted with search terms immunotherapy, chemotherapy and metastatic breast cancer. A filter was used to access articles with free full text that were written within the last five years. The most pertinent articles were selected for this clinical review.

Results: There is not enough research available to prove that estrogen positive metastatic breast cancer tumors respond significantly to immunotherapy. Checkpoint inhibitors, microsatellite instability high, mismatch-deficiency and tumor mutation burden levels are good predictors of response. Patients with those biomarkers may seek treatment when there are no other options.

Conclusion: Additional testing is needed to justify the use of immunotherapy in estrogen positive metastatic breast cancer.

Keywords: Immunotherapy, Metastatic Breast Cancer, Tumor Mutation Burden, Mismatch Repair, Checkpoint Inhibitor.

Target Audience. The target audience is physician assistants and nurse practitioners practicing in oncology.


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