University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Family Medicine, Endocrinology


Dr. Nancy Reid


Aim: The purpose of this article is to review the benefits of initiating metformin in high risk

prediabetes and compare the risk reduction of the progression to diabetes mellitus II (DM II).

Method: A PubMed literature search was conducted with search terms prediabetes, metformin,

high-risk. Twenty-six pertinent articles were retrieved, and they serve as the basis for this

clinical review.

Results: There continues to be varied outcomes in evidence-based research that demonstrate the

need to initiate metformin treatment in addition to lifestyle modification to promote risk

reduction to diabetes in high-risk prediabetics.

Conclusion: Lifestyle modification continues to be the primary method used by clinicians to

prevent diabetes in prediabetics. Current studies show the initiation of metformin treatment along with lifestyle modification, proves to be effective at preventing DM II. Further research is needed to establish long term use of metformin and lifestyle modification in high-risk prediabetics to reduce the risk of diabetes.


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