Family Medicine, Endocrinology
Dr. Nancy Reid
Aim: The purpose of this article is to review the benefits of initiating metformin in high risk
prediabetes and compare the risk reduction of the progression to diabetes mellitus II (DM II).
Method: A PubMed literature search was conducted with search terms prediabetes, metformin,
high-risk. Twenty-six pertinent articles were retrieved, and they serve as the basis for this
Results: There continues to be varied outcomes in evidence-based research that demonstrate the
need to initiate metformin treatment in addition to lifestyle modification to promote risk
reduction to diabetes in high-risk prediabetics.
Conclusion: Lifestyle modification continues to be the primary method used by clinicians to
prevent diabetes in prediabetics. Current studies show the initiation of metformin treatment along with lifestyle modification, proves to be effective at preventing DM II. Further research is needed to establish long term use of metformin and lifestyle modification in high-risk prediabetics to reduce the risk of diabetes.
Caporaso A. Initiating Medication Treatment in Prediabetics with Multiple Risk Factors to Prevent Progression to Diabetes Mellitus II. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2020; 2(4).
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