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Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science

Specialty

Psychiatry

Advisor

Dr. Nancy Reid, MHA, DHSc, PA-C, DFAAPA

Abstract

Treating children with obsessive compulsive disorder (OCD) or tic disorder secondary to pediatric acute-onset neuropsychiatric syndrome (PANS) or pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is challenging. Both conditions are thought to be autoimmune related and differing antibiotic treatment regimens have been utilized for many years with varying levels of success. We conducted a systematic review of free access articles in PubMed® and MEDLINE® using the terms “pediatric neuropsychiatric disorder”, “PANDAS” and “antibiotic”. Twelve research studies and eleven case studies were identified that met the inclusion criteria and were evaluated. Results were mixed. While there are some recommendations from promising case studies and some limited trials, it is evident that more research is needed. A randomized controlled trial (RCT) with various types of antibiotic regimens is highly recommended in order to have an evidence-based treatment regimen to treat children who meet criteria for PANS or PANDAS induced OCD or tic disorder.

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