University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Dr. Thomas Colletti, DHSc, PA-C, DFAAPA


N-methyl-D-aspartate (NMDA) glutamate receptors are ligand-gated and allow for the influx of calcium ions through their respective channels. Glutamate is the most abundant excitatory neurotransmitter in the central nervous system (CNS). NMDA receptor dysfunction is implicated in several neurological and cognitive disorders. There are several subunits of NMDA receptors that have distinct pharmacological properties. This article will focus on NMDAR antagonism for improving cognitive and neurological function using both animal and human models with substances known to be N-methyl-D-aspartate receptor antagonists (NMDARA). In both human and animal models, results prodigiously demonstrated improvement in various types of cognitive dysfunction, neurological disorders, seizure disorders, gene mutation disorders, and mood disorders.


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