University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Family Medicine


Nancy E. Reid, MHA, DHSc, PA-C, DFAAPA


Objectives: The purpose of this article is to review the risks and benefits of treatment for hormone imbalance in women.

Methods: A MEDLINE literature search was conducted with search terms women or female or woman or females, hormone replacement therapy (HRT), risks and benefits, not transgender or transsexual or transexual or gender variant or gender non-conforming. The pertinent articles found serve as the basis for this clinical review.

Results: Evidence demonstrates the benefits of HRT optimization in perimenopausal and menopausal women under age 60 outweigh the risks.

Conclusion: HRT optimization benefits outweigh the risks for most women under 60 years old. There are hormone replacement therapy options that have been shown to be safe and effective. Offering these to women with hormone imbalance can improve quality of life and health outcomes when hormones are optimized.


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