University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Internal Medicine


Nancy E. Reid, MHA, DHSc, PA-C, DFAAPA


Purpose: The purpose of this article is to review the use of probiotic therapy in major depressive disorder (MDD) and its effectiveness in symptom improvement.

Method: A PubMed literature search was conducted using search terms including: depression, probiotics, serotonin, microbiome.

Results: Multiple studies including systematic reviews, randomized controlled trials, and scientific reviews found a positive response to the use of probiotics in improving symptoms of major depressive disorder.

Conclusion: Upon literature review, it is evident that the use of probiotics can produce symptom relief in certain types of clinical depression. This offers another potential realm of therapeutic options for those suffering from depression that may be limited in the types of therapies they are able to use. Data supporting the use of probiotics for certain types of depression also indicates a relationship between mind-gut health. More research is needed on this topic to better understand the mechanisms of depression and the the gut's role in this disease process.


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