University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Nancy E. Reid, MHA, DHSc, PA-C, DFAAPA


Purpose: The purpose of this article is to review the treatment for management of patients with schizophrenia and determine treatments that can improve adherence, in turn reducing relapses and improving outcomes.

Method: A PubMed literature search was conducted with search terms schizophrenia, lai vs oral, and rehospitalization. Eight pertinent articles were retrieved and served as the basis for this clinical review.

Results: Information is present through evidence-based research to support earlier and possibly first line use of long acting injectable antipsychotics to manage schizophrenia.

Conclusion: Schizophrenia is a debilitating psychological condition that presents difficulty to manage, with many patients frequently relapsing. Relapses often lead to permanent cognitive decline and emotional distress for patients and their loved ones. Relapses occur less often, and treatment adherence improves more frequently when using long acting injectable antipsychotics, instead of oral antipsychotics.

Keywords: Schizophrenia, LAI, rehospitalization.


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