Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Medical Oncology


Dr. Thomas Colletti



Purpose: The purpose of this article is to review and discuss the treatment of metastatic and high-risk melanoma over the last 10 years. This includes discussing new immunotherapy options, as well as new targeted therapy.

Method: A PubMed and Google Scholar search was conducted using the terms melanoma, metastatic melanoma, immunotherapy, ipilimumab, nivolumab, pembrolizumab, and targeted therapies.

Results: Significant evidence- based studies demonstrating the efficacy of immunotherapy, such as: ipilimumab, nivolumab, and pembrolizumab in the treatment of metastatic melanoma. In addition, evidence- based studies demonstrating the efficacy of targeted therapies for BRAF mutated melanoma.

Conclusion: The introduction of immunotherapy and targeted therapies in the last 10 years has dramatically changed the prognosis for high risk and metastatic melanoma. Over 50% of patients will respond to these treatments; however, there is still a need for additional therapies for those who are unresponsive to current treatments.

Keywords: ipilimumab, pembrolizumab, nivolumab, melanoma, BRAF


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