University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Orthopedic surgery


Dr. Thomas Colletti



Purpose: The proposed title for this scholarly project is: The impact of hormone replacement therapy on fracture healing.

Method: A PubMed and google scholar literature search was conducted with search terms hormone replacement therapy, fracture healing, osteoporosis, bone healing. Fifteen articles were retrieved and used as basis for this clinical review.

Results: There is evidence to show that sex hormones protect bone health and the loss of these hormones leads to delayed fracture healing. Hormone replacement therapy has also been shown to improve home healing.

Conclusion: The effects of hormone replacement therapy (HRT) in fracture healing have not been well studied. The transgender population is another subset of people in which the effects of HRT on bone healing have not been well studied. Sex steroids are important in the homeostasis of bone and bone mineral density (BMD). Some studies have shown either maintenance or an increase in BMD in both transgender men and transgender females following short-term HRT. Further studies need to be conducted on the effects of hormone replacements on fracture healing.

Keywords: fracture healing, hormone, hormone replacement therapy, non-union.


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