Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Medicine


Dr. Mark Archambault, DHSc, PA-C, DFAAPA


Urinary tract infections (UTIs) remain a commonly encountered world-wide patient complaint within both the inpatient and outpatient setting. Multi-drug resistance to common antibiotics has become a large contributing factor to increases seen in the occurrence and reoccurrence of UTIs. Bacterial pathogens such as Escherichia coli and Enterococcus species are just some of the many organisms that have shown increasing occurrences of multi-drug resistance. Due to the rise of antibiotic resistance amongst these pathogens, alternative antibiotics must be explored to prevent significant morbidity and mortality. Both Fosfomycin and Nitrofurantoin are antibiotics that have shown efficacy against Escherichia coli and Enterococcus species in both complicated and uncomplicated UTIs and should remain potential treatment options when faced with the problem of multi-drug resistance.


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