Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Medicine


Dr. Nancy Reid


Objective This clinical review article reports on existing data and presents those findings with an aim to advise clinicians on a best practice when assessing the cardiac risk versus benefit of testosterone supplementation therapy in middle-aged and elderly men.

Methods Review of clinical literature to observe and report on the history of this therapy and its association with cardiac disease risk versus benefit.

Results Although some research reports an association with increased cardiac risk in men taking testosterone, other research reports the opposite, and indicates that there may be protective effects. To wit, there has been no clear cause and effect relationship established between the use of testosterone and cardiac disease resulting in myocardial infarction.

Conclusion Clinicians should use sound holistic judgement when assessing the risk of heart disease against the benefits of testosterone replacement therapy in middle-aged and elderly men.


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