The Gut-Lung Axis in Pediatric COVID-19: Possible Link and Implications

Authors

Leticia Armendariz Martinez, University of LynchburgFollow

Specialty

Pediatrics

Advisor

Dr. Tom Colletti, DHSc, PA-C, DFAAPA

Abstract

ABSTRACT

Introduction: The purpose of this article is to review the role of the gut-lung axis and the gut microbiome in viral immunity to COVID-19 in SARS-CoV-2 positive children presenting with gastrointestinal (GI) symptoms.

Methodology: The research aim was attained through a review that provides knowledge on the pediatric COVID-19 with GI symptoms from the research field published between 2019-2021. The review includes scientific data addressing the gut-lung axis and the gut microbiome in viral immunity to COVID-19 in positive children presenting with gastrointestinal symptoms (GI) using publicly available peer-reviewed papers found on PubMed.

Results: Evidence suggest that the gut microbiota composition is associated with the immune response to COVID-19. SARS-CoV-2 RNA persists longer in fecal samples than in oropharyngeal samples.

Discussion: Data is still evolving surrounding the transmission rate of COVID-19 by children. Further understanding of the relationship between SARS-CoV-2 and the role of gut microbiota is essential to prevent transmission.

Keywords: pediatric COVID-19, SARS-CoV-2, gut-lung axis, microbiome, gastrointestinal symptoms

Recommended Citation

Armendariz Martinez L. The Gut-Lung Axis in Pediatric COVID-19: Possible Link and Implications. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2021; 3(4).