Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Nancy E. Reid, MHA, DHSc, PA-C, DFAAPA


Background: Depression during perimenopause is common and frequently untreated in women. This article serves to review the current research on perimenopausal and depression treatment for women between the ages of 40 and 60 years.

Method: A clinical review of literature has been conducted.

Conclusion: Early intervention with antidepressants, SSRI’s and/or SNRI’s, with concurrent talk therapy should be considered first line treatment of perimenopausal depression. Primary care providers, women’s health providers, and mental health providers should initiate treatment with an SSRI and refer for therapy at first symptom emergence for best treatment outcome.


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