Complications, Morbidity and Mortality in Surgical or Trauma Patients with Cirrhotic Liver Disease

Authors

Miranda Warunek, University of LynchburgFollow

Specialty

Surgery

Advisor

Dr. Nancy Reid

Abstract

ABSTRACT

Liver cirrhosis is a sequela of chronic exposure to certain offending elements or genetic mutations that promote activation of hepatic stellate cells (HSCs) which are a major source of fibrogenesis and scarring of the liver. This scaring leads to liver dysfunction, which subsequently alters a variety of the normal pathophysiologic functions including coagulation, immune response, cardiac response, and renal response. Understanding the extent of cirrhotic liver dysfunction and how surgery or trauma affects this dysfunctional state in potential surgical and trauma patients may better prepare clinicians to treat these patients and improve overall care and prognosis. This article explores how liver cirrhosis and dysfunction increases patient morbidity and mortality in emergent and non-emergent surgery. Patients with liver dysfunction are at a higher surgical risk with more post-operative complications, poorer prognosis, and higher mortality.

Recommended Citation

Warunek M. Complications, Morbidity and Mortality in Surgical or Trauma Patients with Cirrhotic Liver Disease. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2021; 3(4).