Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Medicine


Dr. Tom Colletti



Purpose: The purpose of this article is to review modern pharmacologic weight management options for non-diabetic adult patients, with respect to efficacy and potential adverse effect risk. This is a systematic review of currently available agents with indications or off-label uses for weight loss, and the potential adverse effects.

Results: There is a multitude of effective therapeutic agents for weight loss. Our research shows that most weight loss was modest, with best results shown when combined with appropriate diet and exercise programs. The addition of medication to behavior modification and lifestyle changes proved more effective at overall weight reduction than diet and exercise alone in most cases.

Conclusion: Administering certain medications can improve weight loss as monotherapy. Adding medication to traditional diet and exercise with weight loss as the goal can help improve results. However, adverse effects remain a concern, and medication prescription must be appropriate to apparent pre-existing comorbidities, and patients must continue to operate under clinical supervision with education pertaining to adverse effects.


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