Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Medicine


Dr. Tom Colletti, DHSc, PA-C, DFAAPA


Major Depressive Disorder (MDD) is the leading cause of disability worldwide. Unfortunately, current prescription depression treatments have a high failure rate. Therefore, other therapeutic options must be considered. Emerging evidence suggests there is a link between the microorganisms in the gastrointestinal tract (also known as gut microbiota) and depression. The objective of this clinical review article is to evaluate the evidence linking gut microbiota and depression as well as to examine the potential benefits of probiotics in the treatment of MDD.


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