University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Dr. Thomas Colletti, DHSc, MPAS, PA-C



Purpose: The purpose of this article is to review the neurological manifestations and complications of COVID-19 infection, and ensure early recognition and appropriate management to prevent long-term neurological consequences.

Method: A literature review was conducted using the PubMed database with search terms ‘COVID- 19, coronavirus, nervous system, and neurological manifestation. Initially, 23 pertinent articles were reviewed but fifteen were selected as the basis for this review article. Others were discarded due to repetition or insignificant information.

Results: Multiple studies to date have reported neurological manifestations and neuroradiologic findings in COVID-19 infections.

Conclusion: There is increasing evidence of central and peripheral nervous system (PNS) involvement due to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. It is important for front-line providers to be more aware of these atypical presentations of COVID-19 infection either with or without respiratory symptoms. Neuropathogenesis is still an evolving knowledge for us; hence requires more research in understanding the neurologic facets of COVID‐19 and formulating appropriate management plans accordingly.


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