University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Internal Medicine


Dr. Elyse Watkins



Purpose: The purpose of this article is to review pharmacotherapy options for the treatment of overweight and obesity.

Method: A PubMed literature search was conducted with search terms including pharmacotherapy, obesity, anti-obesity drugs/medications, Benzphetamine, Diethylpropion, Phendimetrazine, Phentermine, Orlistat, Alli, Xenical, Liraglutide, Saxenda, Semaglutide, Wegovy, Gelesis, Plenity, Phentermine-topiramate, Qsymia, Bupropion-naltrexone, Contrave, Global Obesity, Global Overweight, US obesity, US overweight. Twenty-three articles are identified as pertinent for this review.

Results: Four single-therapy agents are available for short-term weight loss. Four single-therapy and two combination-therapy medications are FDA approved for long-term weight loss management.

Conclusion: Benzphetamine, Diethylpropion, Phendimetrazine, and Phentermine are four short-term therapies approved for use for 12 weeks. Orlistat, Liraglutide, Semaglutide, Gelesis, Phentermine-topiramate, and Bupropion-naltrexone are FDA approved for long-term use for weight loss.


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