University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Administrative Medicine


Dr. Colletti



Background: Chronic cholinergic urticaria is resistant to treatment, and patients can experience significant negative impacts on daily life. Generally, this condition can be diagnosed with a thorough history and physical examination. Then, treatment occurs stepwise, leading from common antihistamines, immunosuppressives, through monoclonal antibodies. In addition, there are several novel treatments on the horizon, including autologous sweat therapy.

Purpose: This article aims to review the diagnosis and treatment of chronic cholinergic urticaria.

Objective: The goal of this paper is to describe critical elements in the history, physical examination, and treatment of chronic cholinergic urticaria.

Methods: This is a clinic review of cholinergic urticaria, including the pathogenesis, diagnosis, treatment, and current and future treatment modalities.

Results: The causes of cholinergic urticaria are uncertain, but studies suggest an allergic reaction to histamine released in sweat or serum. Several randomized controlled clinical trials (RCTs) have demonstrated the benefit of immunosuppressives and monoclonal antibodies in treatment. In addition, a few studies suggest an autoimmune sweat allergy that could benefit from autologous sweat therapy, but future studies are required to confirm this modality as a treatment option.

Conclusion: Chronic cholinergic urticaria can lead to debilitating symptoms impacting daily life. Emerging treatments show promise in providing patients relief from this condition. The goal of publishing this article is to bring greater awareness of this condition, current treatment options, and future opportunities to treat or cure this retractable condition.

Keywords: Allergy, Autologous, Cholinergic, Chronic, Sweat, Urticaria


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