University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Tom Colletti, DHSc, PA-C, DFAAPA


Granuloma annulare (GA) is a benign inflammatory disease that is associated with many comorbidities such as malignancy, trauma, thyroid disease, diabetes mellitus, and HIV infection. GA usually presents with dermal papules and annular plaques in a symmetric distribution most found on the hands, feet, and arms. GA is usually self-limiting and resolves in 50% of patients within two years, although the rate of recurrence is high in this group. The generalized variant of GA can be persistent, sometimes lasting years to decades. For GA being such a common dermatologic condition, we still know very little regarding the etiology and effective treatments. Treatment in these patients have not always shown to be effective. GA has very little research on several types of treatments that show improvement. There are little randomized controlled studies, most performed decades ago. Some of the treatment options proposed for GA include topical steroids, intralesional Kenalog, NUVB, anti-malarials, Janus kinase (JAK) inhibitors, and biologics.


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