University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Internal Medicine


Elyse Watkins


Aplastic anemia (AA), despite its rarity, in most cases is life-threatening if untreated and requires urgent immunosuppressive therapy or bone marrow transplantation. Finding the population at risk for acquired AA remains challenging. The purpose of this article is to review the association between Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and vaccination with onset of acquired AA in a case study. By presenting a case of a 75-year-old female who has been diagnosed with new onset of severe acquired AA fifteen weeks after contracting SARS-CoV-2 infection and five weeks after receiving a SARS-CoV-2 Janssen vaccination, this author is attempting to explore the possibility that SARS-CoV-2 infection, and to a much lesser degree the vaccination, may intercede an immunologic response contributing to AA.


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