University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Dr. Tom Colletti, DHSc, PA-C, DFAAPA


Purpose: The purpose of this paper is to compare several compounds and their efficacy in prevention of contrast induced nephropathy in patients undergoing emergent contrast enhanced contrast procedures.

Method: A PubMed literature search was conducted with the words vitamin c and contrast induced nephropathy. Eleven pertinent articles were retrieved and served as the basis of this clinical review.

Results: While hydration has been the mainstay of prevention of other kidney injuries, other compounds in combination with hydration or by themselves are being investigated for potential benefit in reduction of contrast induced nephropathy.

Conclusions: Contrast induced nephropathy is correlated with heightened morbidity, mortality, and other long term unfavorable effects in patients with chronic kidney disease. Standard hydration has been used for prophylaxis and there is ongoing research to compare other compounds that might have better efficacy when used in combination with standard hydration to prevent Contrast Induced Nephropathy. While other studies have shown that administration of N-Acetyl Cysteine and/or vitamin C before contrast media for elective and therapeutic procedures or imaging studies have little to no significance on the incidences of Contrast Induced Nephropathy, other compounds have shown great promise.


Available when accessing via a campus IP address or logged in with a University of Lynchburg email address.

Off-campus users can also use 'Off-campus Download' button above for access.