Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science


Family Medicine


Bernard Toney Jr., DMSc, PA-C


This article reviews the use of intra-articular corticosteroids in the treatment of osteoarthritis of the knee and introduces intra-articular ketorolac as an alternative. Osteoarthritis of the knee is a major cause of disability among the elderly and the burden of disease will increase in the upcoming decade with an aging population. Currently, recommended treatments include weight loss, activity modification, physical therapy, acetaminophen, NSAIDs, and intra-articular corticosteroid injections. Several recent studies have proposed intra-articular ketorolac as a substitute for intra-articular corticosteroids. Initial results are promising, however, further research is needed to confirm long-term safety.


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