University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository




Larry Herman, DMSc, MPA, PA-C, DFAAPA


Emphysematous cystitis is a rare and complicated urinary tract infection associated with gas formation in the bladder wall. This is commonly associated with poorly controlled diabetes mellitus in elderly women. The case presented involves a male diagnosed with emphysematous cystitis while being treated with empagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), for type-2 diabetes mellitus (T2DM). He was noted to have a past medical history of symptomatic benign prostatic hyperplasia for which he was prescribed tamsulosin. Treatment was non-operative, and he fully recovered with no long-term sequelae. SGLT2i medications have been beneficial in improving glycemic control for patients with T2DM, though the risk for severe urinary tract infections remains controversial. After a review of the literature, only one other case was similar to the one presented.


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