Lynchburg Journal of Medical Science

Lynchburg Journal of Medical Science




Dr. Nancy Reid, MHA, DMSc, PA-C, DFAAPA



Purpose: The purpose of this article is to review the effectiveness of sacubitril/valsartan in improving left ventricular systolic function as compared to cardiac resynchronization therapy (CRT) in adults with cardiomyopathy.

Method: Using the search engine PubMed, the terms sacubitril/valsartan, cardiac resynchronization therapy, and combined sacubritil/valsartan and cardiac resynchronization therapy were searched. Sixteen relevant articles were identified and will serve as the basis for the literature review.

Results: Evidence-based research has shown sacubitril/valsartan to be effective in increasing left ventricular systolic function. However, further research is needed to determine if it is superior to cardiac resynchronization therapy.

Conclusion: Traditional treatment for cardiomyopathy has included the use of beta-blockers, diuretics, and angiotensin-converting enzyme inhibitors along with cardiac resynchronization therapy. Sacubritil/valsartan has received approval from the Food and Drug Administration for the treatment of cardiomyopathy. Studies have reported the effectiveness of sacubitril/valsartan however it is not known if it is superior to cardiac resynchronization therapy.

Keywords: cardiomyopathy, cardiac resynchronization therapy, sacubitril/valsartan


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