University of Lynchburg DMSc Doctoral Project Assignment Repository

University of Lynchburg DMSc Doctoral Project Assignment Repository


Emergency Medicine


Elijah Salzer, DMSc, PA-C, NYSAFE, C-EFM


Obesity rates (BMI > 30kg/m2) are rapidly increasing in United States adults and are associated with a multitude of health problems. (Hypertension, Coronary artery disease, type 2 diabetes, stroke, and cancer).1 Nutritional guidance and lifestyle changes have had dismal success and less than 20% of Americans who lose weight can maintain weight loss for > 1 year.2 Newer medications such as Glucagon-like peptide -1 receptor agonist (GLP-1) have been effective but most patients are referred to surgery for treatment.3 Fasting and time-restricted eating (TRE) (ad libitum caloric intake restricted to 4-12 h/d) have shown to be an effective long-term strategy for maintaining weight loss.4 physiologists have demonstrated that fasting impacts gene expression, such as mammalian target of rapamycin (mTOR). It promotes the autophagy of damaged and senescent cells and can decrease inflammation.5 Mouse models have shown that fasting increased life span and eliminated measurable elements of metabolic syndrome (MS) (Hypertension, Hyperglycemia, hypertriglyceridemia, Low HDL cholesterol and increased abdominal adiposity). 6


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