Dr. Tom Colletti, DHSc, PA-C, DFAAPA
New onset diabetes after transplant (NODAT/PTDM), also known as post-transplant diabetes mellitus (PTDM) is a serious complication that transplant patients may encounter. There are many variables that play a role in the development of this problem: family history, dietary influence- obesity, immunosuppression medications, induction therapies, infection, hypomagnesemia, autosomal -dominant polycystic kidney disease, and HMG CoA reductase inhibitors. Analyses of modifiable and non-modifiable risk factors were reviewed to determine predominant causes of this condition. There are certain characteristics that can predispose a patient to the development of new onset diabetes after transplant and include genetic risk factors, age, body mass index, the diagnosis leading to end stage renal disease and cardiovascular status. Some modifiable risk factors in the post-transplant period include diet, medications, and infectious diseases. NODAT/PTDM is important to diagnose and treat due to potential risk of allograft rejection and the long-term complications that can affect the patient. This includes the cardiovascular risks since this is a major player in death following renal transplantation.
Marku-Podvorica J. Major Factors Leading to New Onset Diabetes after Renal Transplant. University of Lynchburg DMSc Doctoral Project Assignment Repository. 2022; 4(4).
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